Safety and feasibility of treatment simplification to atazanavir/ ritonavir1 lamivudine in HIV-infected patients on stable treatment with two nucleos(t)ide reverse transcriptase inhibitors1atazanavir/ ritonavir with virological suppression (Atazanavir and Lamivudine for treatment Simplification, AtLaS pilot study)
نویسندگان
چکیده
Methods: This was a single-arm pilot study, enrolling 40 patients on atazanavir/ritonavir+two nucleos(t)ide reverse transcriptase inhibitors (NRTIs), without previous treatment failure, with HIV-RNA ,50 copies/mL for .3 months and CD4 .200 cells/mm. At baseline, patients were switched to 300/100 mg of atazanavir/ ritonavir+300 mg of lamivudine once daily. Laboratory parameters, atazanavir plasma levels, self-reported adherence, quality of life, neurocognitive performance, bone composition and body fat distribution were monitored. Virological failure was defined as HIV-RNA .50 copies/mL on two consecutive determinations or a single level .1000 copies/mL.
منابع مشابه
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تاریخ انتشار 2013